How to block pgd2 ?
How to block pgd2? : Androgenic alopecia (AGA), also called male patterned hair loss, is the most common form of hair loss and has been associated with other dysfunctions such as coronary heart disease and enlarged prostate.
Apparently PGD2 inhibits the ripening of hair follicles
There have been a number of studies of androgenic alopecia, but more data is needed to clearly demonstrate a true underlying cause – the key thing (s) that distinguishes a predisposition from the others.
Perelman Medical School at the University of Pennsylvania
In 2012, the University of Pennsylvania published a breakthrough study that resulted in PGD2 reaching normal levels higher than normal in male skulls. PGD2 seems to prevent the hair follicles from mature. This means that PGD2 inhibits the growth of hair follicles. In explant hair rats, PGD2 clearly inhibited hair growth when applied topically. PGD2 causes hair loss when bound to a receptor called GPR33; When activated by PGD2 at high levels, the receptor prevents hair growth.
There are many products marketed for the prevention of hair loss – some contain substances to increase circulation in the head, some contain DHT blockers.
Since the relationship of PGD2 to hair loss has just been discovered, there are not many products available to the market to alleviate this particular problem. However, there are supplements which are accepted as PGD2 blockers and can be used by people suffering from hair loss.
One study analyzed 289 compounds of 12 selected to see if they would work as PTG2 inhibitors. Their properties were analyzed in terms of skin permeability, sensitivity, irritation, corrosion, mutagenicity, tumor identity and reproductive effects. Despite the presence of PGD2 inhibition in the majority, many of them caused adverse reactions and also skin skin permeability. Among these, ricinoleic acid, acteoride, amentoflavone, quercetin and hinokiflavone may be safe and effective for hair loss treatments and good inhibitors with minimal adverse skin reactions (Fong et al., 2015). However, some of the inhibitors presented above remain mysterious, at least in the absence of further studies on efficacy in hair loss treatment or at least new investigations confirming the effects on PGD2.
Fortunately, there are at least other PGD2 inhibitors that can give the answer to the problem of hair loss, with more research behind it to support its effects as an inhibitor.
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